INHIBITION OF THE d-AMINO ACID OXIDASE BY BENZOIC ACID BY J. RAYMOND KLEIN AND HENRY KAMIN
نویسندگان
چکیده
Benzoic acid has been reported to inhibit the oxidation of succinic acid by muscle (l), the oxidation of butyric acid and crotonic acid by liver slices (2), and the oxidation of acetoacetic acid by kidney slices (3). It has also been reported to inhibit the oxygen uptake of liver and kidney slices, diaphragm, minced liver, kidney, and brain (4). In the present work it was found that benzoic acid had a slight inhibitory effect on the oxygen uptake of broken cell preparations of rat liver and kidney. It had no effect on the oxidation of succinic acid, lactic acid, hypoxanthme, xanthine, uric acid, choline, tyramine, I( -)-tyrosine, I( -)-proline, Z( -)-phenylalanine, sarcosine, or ethyl alcohol by the liver preparation. The oxidation of d-amino acids by various preparations of the d-amino acid oxidase was markedly inhibited by benzoic acid.
منابع مشابه
INHIBITION OF THE d-AMINO ACID OXIDASE BY BENZOIC ACID
Benzoic acid has been reported to inhibit the oxidation of succinic acid by muscle (l), the oxidation of butyric acid and crotonic acid by liver slices (2), and the oxidation of acetoacetic acid by kidney slices (3). It has also been reported to inhibit the oxygen uptake of liver and kidney slices, diaphragm, minced liver, kidney, and brain (4). In the present work it was found that benzoic aci...
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